- Ancient Rome: "SAPA": Extraction from fermented wine which is heated and from which magnificant crystals seperate.
- Mid of 19. century (1841-1855): Discovery of Thaumatin
- 1878/79: Discovery of Saccharin
- 1887: Begin of Saccharin-Production at Fahlberg List AG
- 1914 - 1945: World War I and World War II and post war period: sharp rise in the consumption of Saccharin: Saccharin becomes a sought-after comodity becuase of the shortage of sugar.
- 1937: Discovery of Cyclamate
- 1950: Abbott markets Cyclamate under the brand name "Sucaryl".
- 1963: Discovery of Neohespiridine DC
- 1965: Discovery of Aspartame
- 1967: Discovery of Acesulfame K
- 1975: Diet directive permits the use of Saccharin and Cyclamate in certain dietary foodstuffs.
- 1976: Discovery of Sucralose
- 1980: joint technical development of Sucralose by Tate & Lyle and McNeil
- 1994: Entry into force of the EU-Sweeteners Directive
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